Investigation of the Protective Effects of Diosmin Against Emamectin Benzoate Induced Oxidative Damage in Rats

This study was aimed to investigate the effects of diosmin (DIO) in rats exposed emamectin benzoate (EB). For this purpose, a total 60 Wistar Albino male rats, aged 6 8 weeks and weighing 180 250 g, were used, 10 each group. The groups determined, respectively, control, EB (10 mg kg-1), DIO (50 (100 kg-1) + indicated doses applied by gavage for 21 days. At end trial period, heart puncture performed under anesthesia blood samples taken into tubes with heparinized anticoagulant-free properties. liver, kidney, brain, testis, lung tissues removed after cervical dislocation. While some biochemical markers, such as aspartate aminotrans- ferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), triglyceride, cholesterol, protein, albumin, uric acid, urea nitrogen (BUN) and, creatinine assessed serum, oxidative stress indicators, MDA, NO, SOD, CAT, GSH-Px, GR, GST, GSH, determined tissue samples. investigation, no changes between parameters control group discovered. Comparing group, it found that levels MDA NO tissues/ erythrocytes had significantly increased. activity CAT enzymes, well GSH levels, have decreased. Furthermore, serum protein albumin reduced, although AST, ALT, ALP, LDH, BUN, levels/activities elevated. Depend- ing on dose, values coadministered EMB close those In conclusion, is proposed could provide protection against EMB-induced toxicity rats.